Healthcare is one of the most vital—and capital-intensive—sectors on the planet. But what happens when you apply a focused, seed-stage venture capital lens to it? According to Todd Perman, Managing Partner at SEED Healthcare, you unlock the power of early intervention, long-term alignment, and transformative potential.
In this episode of 0100 Impact Talks, Todd breaks down the philosophy behind SEED Healthcare, a venture capital firm dedicated to backing entrepreneurs at the intersection of healthcare, science, and engineering.
Unlike many healthcare VCs that wait for clinical or commercialization milestones, SEED embraces risk earlier in the lifecycle. “We believe the most value—and the most alignment—happens at seed,” Todd explains. SEED typically invests $500K–$1.5M and takes an active role from day one.
This early-stage conviction allows SEED to partner with founders long before others are willing to commit—often when the science is still transitioning from lab to real-world application.
Todd emphasizes that SEED’s sweet spot lies in health innovation that’s deeply technical. “We want to back companies that are science- or engineering-led, not just software wrapping around workflows,” he says.
These include everything from diagnostics and devices to digital health and AI applications with real-world medical implications. The firm’s investment team, which includes a former Stanford radiologist and operators with IPO experience, reflects this interdisciplinary approach.
Todd is candid about the founder-first ethos at SEED: “Healthcare is one of the hardest verticals to build in. If you don’t believe in the person and their story, it’s hard to get conviction.” He shares how lived experiences—like a founder losing a loved one to a misdiagnosis—can often become the fuel behind breakthrough companies.
SEED looks for founders with a rare mix of scientific depth, operational stamina, and emotional intelligence. “We’re not afraid to invest in underdogs,” Todd notes.
The conversation also explores the growing interest from family offices in healthcare-focused VC. “Family offices understand legacy, they understand long timelines, and they often want to be closer to impact,” says Todd. SEED’s mission-driven focus and high-touch model resonates with this profile.
While SEED isn’t an impact fund in the traditional sense, its investments often target major public health gaps. “We care deeply about alignment. Our companies aim to improve access, reduce costs, or increase clinical outcomes,” Todd explains. This broader sense of purpose attracts LPs who want to blend return with relevance.
With Fund II in the works and a growing portfolio of breakout companies, SEED is doubling down on its niche. Todd closes the episode with optimism: “If we can keep supporting these scientists and operators early, the downstream ripple effects will be enormous.”
he third edition of 0100 International — organized by Zero One Hundred Conferences in partnership with the Milan City Council’s Department of Economic Development and Milano&Partners — brought together the global private markets community for a high-signal, execution-focused gathering held from October 27–29.
François Candelon, Partner for Value Creation & Portfolio Monitoring at Seven2, shares how the firm aligns every investment around a clear “exit animal”—a vision of the company at exit—and uses disciplined execution, AI-driven transformation, and sustainability as levers for resilience and premium valuations. From reengineering core processes with AI to embedding decarbonization into business strategy, Candelon explains how Seven2 builds companies that are not just exit-ready, but future-proof.
Private markets are entering a new era where trust, compliance, and technology converge. While public markets enjoy automation and transparency, private assets still depend on paper-based, fragmented systems. Antonio Chiarello, CEO of Weltix, argues that the next leap forward is not just digitization, but the creation of digital infrastructures that redefine ownership. In this conversation, he discusses why friction is structural rather than technological, how regulation enables innovation, and how programmable liquidity and transparency can channel more private capital into real economic growth.
